kWIP, or the k-mer weighted inner product, is a method of estimating genetic distance directly from modern sequencing data.

kWIP Overview

The paper for kWIP is now published in PLoS Computational Biology (doi:10.1371/journal.pcbi.1005727). We show that kWIP performs well on low-moderate coverage whole-genome population re-sequencing data, accurately estimating genetic distances.

kWIP is open source, and available from my GitHub page.